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Antimicrobial Agents and Chemotherapy, March 2004, p. 1028-1031, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1028-1031.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of attP in Integrase-Mediated Integration of the Shigella Resistance Locus Pathogenicity Island of Shigella flexneri

Sally A. Turner, Shelley N. Luck, Harry Sakellaris, Kumar Rajakumar,{dagger} and Ben Adler*

Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Victoria 3800, Australia

Received 1 August 2003/ Returned for modification 23 October 2003/ Accepted 5 November 2003

The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.

* Corresponding author. Mailing address: Department of Microbiology, Building 53, Monash University, Victoria 3800, Australia. Phone: 61-3-99054815. Fax: 61-3-99054811. E-mail: Ben.Adler{at}med.monash.edu.au.

{dagger} Present address: Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1028-1031, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1028-1031.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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