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Antimicrobial Agents and Chemotherapy, March 2004, p. 1037-1039, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1037-1039.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of New Quinolones and Oxazolidinones against Actinomadura madurae

Lucio Vera-Cabrera,1* Elsa Y. Ochoa-Felix,1,2 Gloria Gonzalez,2 Rolando Tijerina,2 Sung H. Choi,3 and Oliverio Welsh1

Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario,1 Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México,3 Research Laboratory, Dong-A Pharmaceutical Company, Limited, Yongin, Korea2

Received 20 June 2003/ Returned for modification 12 November 2003/ Accepted 25 November 2003

In this work, we studied the in vitro sensitivity of 24 strains of Actinomadura madurae to a new oxazolidinone (DA-7867), gatifloxacin, moxifloxacin, and garenoxacin by using a broth microdilution method. We observed that the A. madurae strains had a high level of sensitivity to all the antimicrobials tested. The most active drug was DA-7867, with a MIC at which 90% of the strains are inhibited (MIC90) of 0.125 µg/ml and a MIC50 of 0.06 µg/ml.

* Corresponding author. Mailing address: Servicio de Dermatología, Hospital Universitario, Madero y Gonzalitos, Colonia Mitras Centro, C.P. 64460, Monterrey, N.L., México. Phone: 5281 8348 0383. Fax: 5281 8348 44 07. E-mail: luvera_99{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1037-1039, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1037-1039.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vera-Cabrera, L., Brown-Elliott, B. A., Wallace, R. J. Jr., Ocampo-Candiani, J., Welsh, O., Choi, S. H., Molina-Torres, C. A. (2006). In Vitro Activities of the Novel Oxazolidinones DA-7867 and DA-7157 against Rapidly and Slowly Growing Mycobacteria. Antimicrob. Agents Chemother. 50: 4027-4029 [Abstract] [Full Text]  
  • Vera-Cabrera, L., Gonzalez, E., Rendon, A., Ocampo-Candiani, J., Welsh, O., Velazquez-Moreno, V. M., Hak Choi, S., Molina-Torres, C. (2006). In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis. Antimicrob. Agents Chemother. 50: 3170-3172 [Abstract] [Full Text]  


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