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Antimicrobial Agents and Chemotherapy, March 2004, p. 1058-1060, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1058-1060.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibition of ß-Lactamase II of Bacillus cereus by Penamaldic Derivatives of Penicillins

Pilar Gutiérrez Navarro,* Bartolomé Quintero Osso, Raquel García Ortiz, Pedro J. Martínez de las Parras, María I. Martínez Puentedura, and M. Carmen Cabeza González

Department of Physical Chemistry, School of Pharmacy, University of Granada, E-18071 Granada, Spain

Received 26 May 2003/ Returned for modification 30 June 2003/ Accepted 24 November 2003

The penamaldic derivatives of amoxicillin, ampicillin, and penicillins G and V, stabilized with Zn2+, were obtained from a methanolic medium. The enzymatic kinetic results show that the these derivatives elicit reversible inhibition of the enzyme metallo-ß-lactamase from Bacillus cereus, with inhibition constant values determined at pH 7.0 and 25°C.

* Corresponding author. Mailing address: Department of Physical Chemistry, School of Pharmacy, University of Granada, E-18071 Granada, Spain. Phone: 34-58-243827. Fax: 34-58-244090. E-mail: mpgn{at}platon.ugr.es.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1058-1060, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1058-1060.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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