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Antimicrobial Agents and Chemotherapy, March 2004, p. 1061-1064, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1061-1064.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activities of Dalbavancin In Vitro and in a Rabbit Model of Experimental Endocarditis Due to Staphylococcus aureus with or without Reduced Susceptibility to Vancomycin and Teicoplanin

Agnès Lefort,* Juliette Pavie, Louis Garry, Françoise Chau, and Bruno Fantin

Faculté de Médecine Xavier Bichat and University Paris VII, 75018 Paris, France

Received 18 April 2003/ Returned for modification 24 August 2003/ Accepted 12 November 2003

For the treatment of rabbit endocarditis, dalbavancin given once daily (10 mg/kg of body weight for 4 days) or as a single 40-mg/kg dose was active against Staphylococcus aureus with or without reduced susceptibility to glycopeptides, as expected from its good in vitro activity, even in broth supplemented with 90% serum and given its prolonged elimination half-life.

* Corresponding author. Present address: Service de Médecine Interne, Hôpital Beaujon, 100 Boulevard du Général Leclerc, 92118 Clichy Cedex, France. Phone: 33-1-40-87-58-90. Fax: 33-1-40-87-10-81. E-mail: aglefort{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1061-1064, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1061-1064.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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