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Antimicrobial Agents and Chemotherapy, March 2004, p. 903-908, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.903-908.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Tetracycline and Streptomycin Resistance Genes, Transposons, and Plasmids in Salmonella enterica Isolates from Animals in Italy

Cristina Pezzella,1 Antonia Ricci,2 Elisabetta DiGiannatale,3 Ida Luzzi,1 and Alessandra Carattoli1*

Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome,1 Istituto Zooprofilattico Sperimentale delle Venezie, Padua,2 Istituto Zooprofilattico Sperimentale di Abruzzo e Molise, Teramo, Italy3

Received 24 July 2003/ Returned for modification 9 October 2003/ Accepted 11 November 2003

Fifty-eight multidrug-resistant Salmonella enterica strains of 20 serotypes, isolated from animal sources in Italy, were analyzed for tet(A) and strA-strB, conferring tetracycline and streptomycin resistance, respectively. The strA and strB genes were highly prevalent in Salmonella strains of our collection, being detected in 84% of the streptomycin-resistant strains. In many strains, the strA and strB genes were linked to a particular Tn5393-derivative transposon characterized by the presence of the insertion sequence IS1133, previously identified only in the plant pathogen Erwinia amylovora. Sixty-eight percent of the tetracycline-resistant strains were tet(A) positive, indicating that this gene is widely diffused in Salmonella strains circulating in animals in Italy. Most of the tet(A) genes were localized within a deleted Tn1721 transposon variant. Two prevalent repN and repI1 resistance plasmids were identified in Salmonella isolates of our collection.

* Corresponding author. Mailing address: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy. Phone: 39-06-4990-3128. Fax: 39-06-4938-7112. E-mail: alecara{at}iss.it.

Antimicrobial Agents and Chemotherapy, March 2004, p. 903-908, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.903-908.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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