This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ricci, V. Articles by Piddock, L. J. V. Search for Related Content PubMed PubMed Citation Articles by Ricci, V. Articles by Piddock, L. J. V.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2004, p. 1344-1346, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1344-1346.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of Topoisomerase Mutations and Efflux in Fluoroquinolone Resistance of Bacteroides fragilis Clinical Isolates and Laboratory Mutants

Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom,¹ University of Minnesota, Minneapolis, Minnesota 55455,² Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90024³

Received 21 May 2003/ Returned for modification 22 November 2003/ Accepted 19 December 2003

Twelve laboratory mutants and 32 ciprofloxacin-resistant isolates of Bacteroides fragilis were examined for the mechanism(s) of fluoroquinolone resistance. Five mutants had mutations in gyrA. One mutant and two clinical isolates contained a mutation in gyrB. Eight mutants and five clinical isolates accumulated significantly less ciprofloxacin than did wild-type isolates; the mutants and clinical isolates were restored to wild-type characteristics when carbonyl cyanide m-chlorophenylhydrazone was used.

This article has been cited by other articles:

• Wexler, H. M. (2007). Bacteroides: the Good, the Bad, and the Nitty-Gritty. Clin. Microbiol. Rev. 20: 593-621 [Abstract] [Full Text]  
• Pumbwe, L., Glass, D., Wexler, H. M. (2006). Efflux Pump Overexpression in Multiple-Antibiotic-Resistant Mutants of Bacteroides fragilis.. Antimicrob. Agents Chemother. 50: 3150-3153 [Abstract] [Full Text]  
• Pumbwe, L., Chang, A., Smith, R. L., Wexler, H. M. (2006). Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates. J Antimicrob Chemother 58: 543-548 [Abstract] [Full Text]  
• Pumbwe, L., Ueda, O., Yoshimura, F., Chang, A., Smith, R. L., Wexler, H. M. (2006). Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance. J Antimicrob Chemother 58: 37-46 [Abstract] [Full Text]  
• Poole, K. (2005). Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56: 20-51 [Abstract] [Full Text]  
• Gruger, T., Nitiss, J. L., Maxwell, A., Zechiedrich, E. L., Heisig, P., Seeber, S., Pommier, Y., Strumberg, D. (2004). A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II. Antimicrob. Agents Chemother. 48: 4495-4504 [Abstract] [Full Text]  
• Peric, M., Jacobs, M. R., Appelbaum, P. C. (2004). Antianaerobic Activity of a Novel Fluoroquinolone, WCK 771, Compared to Those of Nine Other Agents. Antimicrob. Agents Chemother. 48: 3188-3192 [Abstract] [Full Text]