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Antimicrobial Agents and Chemotherapy, April 2004, p. 1347-1349, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1347-1349.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mutations in a 23S rRNA Gene of Chlamydia trachomatis Associated with Resistance to Macrolides

O. Y. Misyurina,1 E. V. Chipitsyna,2 Y. P. Finashutina,1 V. N. Lazarev,1,3 T. A. Akopian,3 A. M. Savicheva,2 and V. M. Govorun1,3*

Research Institute of Physico-Chemical Medicine, Russian Federation Ministry of Health,1 Lytech Ltd., Moscow,3 The D. O. Ott Research Institute of Obstetrics and Gynaecology, Russian Academy of Medical Sciences, Saint-Petersburg, Russia2

Received 16 August 2003/ Returned for modification 29 October 2003/ Accepted 5 December 2003

For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.

* Corresponding author. Mailing address: Research Institute of Physico-Chemical Medicine, 1a Malaya Pirogovskaya St., Moscow 119992, Russia. Phone: 7 095 245 4236. Fax: 7 095 246 4501. E-mail: govorun{at}hotmail.ru.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1347-1349, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1347-1349.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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