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Antimicrobial Agents and Chemotherapy, April 2004, p. 1357-1360, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1357-1360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to ß-Lactams

Youichi Sato, Hirofumi Shibata, Naokatu Arakaki, and Tomihiko Higuti*

Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan

Received 27 August 2003/ Returned for modification 11 November 2003/ Accepted 19 December 2003

We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to ß-lactam antibiotics from 8- to 32,800-fold.

* Corresponding author. Mailing address: Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. Phone: 81-88-633-7254. Fax: 81-88-633-9550. E-mail: thiguti{at}ph.tokushima-u.ac.jp.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1357-1360, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1357-1360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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