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Antimicrobial Agents and Chemotherapy, April 2004, p. 1374-1378, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1374-1378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of the Gene Encoding a New AmpC ß-Lactamase in a Clinical Strain of Acinetobacter Genomic Species 3

Alejandro Beceiro,1 Lourdes Dominguez,1 Anna Ribera,2 Jordi Vila,2 Francisca Molina,1 Rosa Villanueva,1 Jose Maria Eiros,1 and German Bou1*

Servicio de Microbiología. Complejo Hospitalario Universitario Juan Canalejo, 15006 La Coruña,1 Servicio de Microbiología, Hospital Clinic, 08036 Barcelona, Spain2

Received 4 July 2003/ Returned for modification 28 September 2003/ Accepted 8 January 2004

A presumptive chromosomal cephalosporinase (pI, 9.0) from a clinical strain of Acinetobacter genomic species 3 (AG3) is reported. The nucleotide sequence of this ß-lactamase shows for the first time the gene encoding an AmpC enzyme in AG3. In addition, the biochemical properties of the novel AG3 AmpC ß-lactamase are reported

* Corresponding author. Mailing address: Servicio de Microbiología, Complejo Hospitalario Universitario Juan Canalejo, C/ Xubias de Arriba s/n, 15006 La Coruña, Spain. Phone: 981-178000, ext. 21144. Fax: 981-178216. E-mail: germanbou{at}canalejo.org.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1374-1378, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1374-1378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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