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Antimicrobial Agents and Chemotherapy, April 2004, p. 1379-1381, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1379-1381.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Reduction in Glycopeptide Resistance in Vancomycin-Resistant Enterococci as a Result of vanA Cluster Rearrangements

Wee Gyo Lee,* Ji Young Huh, Sung Ran Cho, and Young Ae Lim

Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea

Received 24 September 2003/ Returned for modification 5 November 2003/ Accepted 29 December 2003

The molecular characterization of five clinical isolates of vanA-containing vancomycin-resistant enterococci with altered resistance to glycopeptides was examined. One strain represented an IS1216V insertion accompanied by partial deletion of the reading frame of vanX following a transposition event. The other four strains represented IS1216V within the vanX-vanY intergenic region associated with deletion of vanY or vanZ.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Ajou University Hospital, San 5, Wonchun-Dong, Paldal-Gu, Suwon 442-749, South Korea. Phone: 82-31-219-5785. Fax: 82-31-219-5778. E-mail: weegyo{at}ajou.ac.kr.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1379-1381, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1379-1381.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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