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Antimicrobial Agents and Chemotherapy, April 2004, p. 1384-1396, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1384-1396.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Antimicrobial Activity of Doripenem, a New Carbapenem

Yigong Ge,1 Matthew A. Wikler,1 Daniel F. Sahm,2 Renée S. Blosser-Middleton,2 and James A. Karlowsky2*

Peninsula Pharmaceuticals, Alameda, California 94502,1 Focus Technologies, Herndon, Virginia 201712

Received 13 October 2003/ Returned for modification 26 November 2003/ Accepted 22 December 2003

The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 µg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 µg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 µg/ml for oxacillin-resistant staphylococci (n = 64), from <=0.008 to 0.06 µg/ml for penicillin-susceptible streptococci (n = 132), and from 1 to 4 µg/ml for penicillin-resistant streptococci (n = 51). Overall, doripenem demonstrated in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.

* Corresponding author. Mailing address: Focus Technologies, Inc., 13665 Dulles Technology Dr., Suite 200, Herndon, VA 20171-4603. Phone: (703) 480-2575. Fax: (703) 480-2654. E-mail: jkarlowsky{at}focustechnologies.com.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1384-1396, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1384-1396.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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