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Antimicrobial Agents and Chemotherapy, April 2004, p. 1397-1399, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1397-1399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Reduced Triclosan Susceptibility in Methicillin-Resistant Staphylococcus epidermidis

Molly B. Schmid and Nachum Kaplan*

Affinium Pharmaceuticals, Inc., Toronto, Ontario M5J 1V6, Canada

Received 3 September 2003/ Returned for modification 14 October 2003/ Accepted 24 December 2003

Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC50) of 0.12 µg/ml and a MIC90 of 0.25 µg/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC50 of 0.12 µg/ml and a MIC90 of 8 µg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.

* Corresponding author. Mailing address: Affinium Pharmaceuticals, Inc., 100 University Ave., 12th Floor, North Tower, Toronto, ON M5J 1V6, Canada. Phone: (416) 645-6649. Fax: (416) 646-1553. E-mail: nkaplan{at}afnm.com.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1397-1399, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1397-1399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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