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Antimicrobial Agents and Chemotherapy, April 2004, p. 1406-1409, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1406-1409.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Molecular Analysis of Metallo-ß-Lactamase Gene bla_SPM-1-Surrounding Sequences from Disseminated Pseudomonas aeruginosa Isolates in Recife, Brazil

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France,¹ Department of Tropical Medicine, Federal University of Pernambuco, Recife, Brazil²

Received 17 July 2003/ Returned for modification 8 October 2003/ Accepted 22 December 2003

The spread of clonally related carbapenem-resistant Pseudomonas aeruginosa producing the metallo-ß-lactamase SPM-1 was found in Recife, Brazil. Upstream of bla_SPM-1, a novel common region (CR4) was identified, comprising an open reading frame, orf495, whose product shares significant identity with putative recombinases, such as Orf513. CR4 may be responsible for mobilization and expression of bla_SPM-1.

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