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Antimicrobial Agents and Chemotherapy, April 2004, p. 1406-1409, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1406-1409.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Molecular Analysis of Metallo-ß-Lactamase Gene blaSPM-1-Surrounding Sequences from Disseminated Pseudomonas aeruginosa Isolates in Recife, Brazil

Laurent Poirel,1 Marcelo Magalhaes,2 Miguel Lopes,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France,1 Department of Tropical Medicine, Federal University of Pernambuco, Recife, Brazil2

Received 17 July 2003/ Returned for modification 8 October 2003/ Accepted 22 December 2003

The spread of clonally related carbapenem-resistant Pseudomonas aeruginosa producing the metallo-ß-lactamase SPM-1 was found in Recife, Brazil. Upstream of blaSPM-1, a novel common region (CR4) was identified, comprising an open reading frame, orf495, whose product shares significant identity with putative recombinases, such as Orf513. CR4 may be responsible for mobilization and expression of blaSPM-1.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1406-1409, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1406-1409.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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