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Antimicrobial Agents and Chemotherapy, April 2004, p. 1419-1421, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1419-1421.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Eradication of Streptococcus pneumoniae in the Nasopharyngeal Flora of Children with Acute Otitis Media after Amoxicillin-Clavulanate Therapy

Itzhak Brook^* and Alan E. Gober

Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C. 20016

Received 24 July 2003/ Returned for modification 30 November 2003/ Accepted 24 December 2003

Nasopharyngeal cultures were obtained from 60 children with acute otitis media before and after treatment with either 45 or 90 mg of amoxicillin (given as amoxicillin-clavulanate) per kg of body weight per day for 10 days. The number of Streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (P = 0.0261) in the 90-mg/kg group.

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* Corresponding author. Mailing address: Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St., NW, Washington, DC 20016. Phone: (301) 295-2698. Fax: (253) 981-8709. E-mail: ib6{at}georgetown.edu.

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Antimicrobial Agents and Chemotherapy, April 2004, p. 1419-1421, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1419-1421.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.