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Antimicrobial Agents and Chemotherapy, April 2004, p. 1422-1425, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1422-1425.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

2'-Fluoro-2'-Deoxycytidine Inhibits Borna Disease Virus Replication and Spread

Jeffrey J. Bajramovic,1,{dagger} Romain Volmer,1,{dagger} Sylvie Syan,1 Sylvie Pochet,2 and Daniel Gonzalez-Dunia1,3*

Unité des Virus Lents, CNRS URA 1930,1 Unité de Chimie Organique, CNRS URA 2128, Institut Pasteur, Paris,2 INSERM U563, CPTP, Toulouse, France3

Received 1 July 2003/ Returned for modification 23 October 2003/ Accepted 16 December 2003

Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-ß-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.

* Corresponding author. Mailing address: INSERM U563, CPTP Batiment B, Place du Dr. Baylac, 31300 Toulouse, Cedex 3, France. Phone: 33-5-6274-4511. Fax: 33-5-6177-9291. E-mail: Daniel.Dunia{at}toulouse.inserm.fr.

{dagger} J.J.B. and R.V. contributed equally to this work.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1422-1425, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1422-1425.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Volmer, R., Bajramovic, J. J., Schneider, U., Ufano, S., Pochet, S., Gonzalez-Dunia, D. (2005). Mechanism of the Antiviral Action of 1-{beta}-D-Arabinofuranosylcytosine on Borna Disease Virus. J. Virol. 79: 4514-4518 [Abstract] [Full Text]  


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