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Antimicrobial Agents and Chemotherapy, May 2004, p. 1865-1868, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1865-1868.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Natural Polymorphism of Cytomegalovirus DNA Polymerase Lies in Two Nonconserved Regions Located between Domains Delta-C and II and between Domains III and I

Anne-Marie Fillet,^1* Laetitia Auray,¹ Sophie Alain,² Karine Gourlain,¹ Berthe Marie Imbert,³ Fatiha Najioullah,⁴ Gael Champier,² Stéphanie Gouarin,⁵ Jocelyne Carquin,⁶ Nadhira Houhou,⁷ Isabelle Garrigue,⁸ Alexandra Ducancelle,⁹ Danielle Thouvenot,⁴ and Marie-Christine Mazeron⁹

Virology Laboratories, Hospital AP-HP Pitié-Salpêtrière and University Paris VI,¹ Hospital AP-HP Bichat-Claude Bernard,⁷ Hospital AP-HP Lariboisière, Paris,⁹ Teaching hospital, Limoges,² Teaching hospital, Nantes,³ Domaine Rockefeller, Lyon,⁴ Hospital Clemenceau, Caen,⁵ Hospital Robert Debré, Reims,⁶ Hospital Pellegrin, Bordeaux, France⁸

Received 6 October 2003/ Returned for modification 13 November 2003/ Accepted 8 January 2004

We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.

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* Corresponding author. Mailing address: Virology Department, Pitié-Salpêtrière Hospital, 83 Bld de l'Hôpital, 75651 Paris Cedex 13, France. Phone: 33 1 42 17 74 02. Fax: 33 1 42 17 74 11. E-mail: anne-marie.fillet{at}psl.ap-hop-paris.fr.

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Antimicrobial Agents and Chemotherapy, May 2004, p. 1865-1868, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1865-1868.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

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