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Antimicrobial Agents and Chemotherapy, May 2004, p. 1865-1868, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1865-1868.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Natural Polymorphism of Cytomegalovirus DNA Polymerase Lies in Two Nonconserved Regions Located between Domains Delta-C and II and between Domains III and I

Anne-Marie Fillet,1* Laetitia Auray,1 Sophie Alain,2 Karine Gourlain,1 Berthe Marie Imbert,3 Fatiha Najioullah,4 Gael Champier,2 Stéphanie Gouarin,5 Jocelyne Carquin,6 Nadhira Houhou,7 Isabelle Garrigue,8 Alexandra Ducancelle,9 Danielle Thouvenot,4 and Marie-Christine Mazeron9

Virology Laboratories, Hospital AP-HP Pitié-Salpêtrière and University Paris VI,1 Hospital AP-HP Bichat-Claude Bernard,7 Hospital AP-HP Lariboisière, Paris,9 Teaching hospital, Limoges,2 Teaching hospital, Nantes,3 Domaine Rockefeller, Lyon,4 Hospital Clemenceau, Caen,5 Hospital Robert Debré, Reims,6 Hospital Pellegrin, Bordeaux, France8

Received 6 October 2003/ Returned for modification 13 November 2003/ Accepted 8 January 2004

We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.

* Corresponding author. Mailing address: Virology Department, Pitié-Salpêtrière Hospital, 83 Bld de l'Hôpital, 75651 Paris Cedex 13, France. Phone: 33 1 42 17 74 02. Fax: 33 1 42 17 74 11. E-mail: anne-marie.fillet{at}psl.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, May 2004, p. 1865-1868, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1865-1868.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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