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Antimicrobial Agents and Chemotherapy, May 2004, p. 1869-1871, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1869-1871.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro

University of Alabama School of Medicine, Birmingham, Alabama 35233,¹ Veterans Affairs San Diego Healthcare System and the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0676²

Received 2 October 2003/ Returned for modification 18 December 2003/ Accepted 21 January 2004

A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.

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