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Antimicrobial Agents and Chemotherapy, May 2004, p. 1876-1878, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1876-1878.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Virulence of Metallo-ß-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo

S. Aoki,1,2 Y. Hirakata,1,2* A. Kondoh,1,2 N. Gotoh,3 K. Yanagihara,2 Y. Miyazaki,2 K. Tomono,2 Y. Yamada,1 S. Kohno,2 and S. Kamihira1

Department of Laboratory Medicine,1 Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501,2 Department of Microbiology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan3

Received 8 December 2003/ Returned for modification 10 December 2003/ Accepted 8 January 2004

We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-ß-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of blaIMP did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with P. aeruginosa carrying blaIMP.

* Corresponding author. Mailing address: 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Phone: 81-95-849-7418. Fax: 81-95-849-7257. E-mail: hirakata{at}net.nagasaki-u.ac.jp.

Antimicrobial Agents and Chemotherapy, May 2004, p. 1876-1878, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1876-1878.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Walsh, T. R., Toleman, M. A., Poirel, L., Nordmann, P. (2005). Metallo-{beta}-Lactamases: the Quiet before the Storm?. Clin. Microbiol. Rev. 18: 306-325 [Abstract] [Full Text]  


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