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Antimicrobial Agents and Chemotherapy, May 2004, p. 1887-1888, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1887-1888.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Development of a Liposome Formulation of Ethambutol

Theresa Wiens,1 Thomas Redelmeier,2 and Yossef Av-Gay1*

Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3J5,1 Northern Lipids Inc., Vancouver, British Columbia, Canada V6S 2L22

Received 10 November 2003/ Returned for modification 29 December 2003/ Accepted 14 January 2004

A liposomal formulation capable of encapsulating 76 to 92% of the antimycobacterial drug ethambutol and showing prolonged in vitro release kinetics is described. In vitro efficacy is equivalent to that of the free drug, suggesting that encapsulation of ethambutol has the potential to shorten the current regimens for tuberculosis.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St., Vancouver, B.C., Canada V5Z 3J5. Phone: (604) 875-4329. Fax: (604) 875-4013. E-mail: yossi{at}interchange.ubc.ca.

Antimicrobial Agents and Chemotherapy, May 2004, p. 1887-1888, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1887-1888.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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