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Antimicrobial Agents and Chemotherapy, May 2004, p. 1889-1891, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1889-1891.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differential Expression Levels of MRP1, MRP4, and MRP5 in Response to Human Immunodeficiency Virus Infection in Human Macrophages

Sylvie Jorajuria,1 Nathalie Dereuddre-Bosquet,2 Karen Naissant-Storck,2 Dominique Dormont,1 and Pascal Clayette2*

CEA, Service de Neurovirologie, Université Paris XI, CRSSA, EPHE, IPSCSPI-BIO, c/o Service de Neurovirologie,1 CEA, Fontenay-aux-Roses, France2

Received 29 July 2003/ Returned for modification 28 October 2003/ Accepted 3 February 2004

Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.

* Corresponding author. Mailing address: SPI-BIO c/o Service de Neurovirologie, CEA, DSV/DRM, 18, route du Panorama, B.P. 6, 92265 Fontenay-aux-Roses Cedex, France. Phone: 33 (0)1 46 54 87 69. Fax: 33 (0)1 46 54 77 26. E-mail: clayette{at}dsvidf.cea.fr.

Antimicrobial Agents and Chemotherapy, May 2004, p. 1889-1891, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1889-1891.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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