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Antimicrobial Agents and Chemotherapy, May 2004, p. 1892-1894, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1892-1894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Iron Blocks the Accumulation and Activity of Tetracyclines in Bacteria

Angela M. Avery, Helen J. Goddard, Edward R. Sumner, and Simon V. Avery*

School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom

Received 25 July 2003/ Returned for modification 20 October 2003/ Accepted 9 January 2004

The apparent sensitivities of several bacterial pathogens to tetracyclines varied by up to 128-fold with the medium content of Fe, but not of other metals. The effect of Fe was independent of superoxide dismutase activity and of intracellular Fe, but accumulation of tetracyclines was blocked in high-Fe medium. Thus, synergistic suppression of bacterial growth in the presence of a low Fe concentration and tetracyclines arises because of elevated antibiotic accumulation.

* Corresponding author. Mailing address: School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Phone: 44-115-9513315. Fax: 44-115-9513251. E-mail: Simon.Avery{at}nottingham.ac.uk.

Antimicrobial Agents and Chemotherapy, May 2004, p. 1892-1894, Vol. 48, No. 5
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.5.1892-1894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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