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Antimicrobial Agents and Chemotherapy, June 2004, p. 2140-2143, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2140-2143.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Efficacies of Amphotericin B (AMB) Lipid Complex, AMB Colloidal Dispersion, Liposomal AMB, and Conventional AMB in Treatment of Murine Coccidioidomycosis

Gloria M. González,1,2* Rolando Tijerina,2 Laura K. Najvar,1 Rosie Bocanegra,1 Michael G. Rinaldi,3 and John R. Graybill1

Department of Medicine, Division of Infectious Diseases,1 Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900,3 Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo Léon, Mexico2

Received 18 August 2003/ Returned for modification 22 September 2003/ Accepted 17 February 2004

The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (P < 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (P < 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis.

* Corresponding author. Mailing address: Facultad de Medicina, Universidad Autónoma de Nuevo León, Departamento de Microbiología, Madero y Dr. E. A. Pequeño s/n, Colonia Mitras Centro, Monterrey, Nuevo León, Mexico 64460. Phone: (5281) 8329 4166. Fax: (5281) 8348 5477. E-mail: gmglez{at}yahoo.com.mx.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2140-2143, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2140-2143.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Olson, J. A., Adler-Moore, J. P., Jensen, G. M., Schwartz, J., Dignani, M. C., Proffitt, R. T. (2008). Comparison of the Physicochemical, Antifungal, and Toxic Properties of Two Liposomal Amphotericin B Products. Antimicrob. Agents Chemother. 52: 259-268 [Abstract] [Full Text]  


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