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Antimicrobial Agents and Chemotherapy, June 2004, p. 2292-2294, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2292-2294.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Salmonella Gene rma (ramA) and Multiple-Drug-Resistant Salmonella enterica Serovar Typhimurium

Tahar van der Straaten,1 Riny Janssen,1 Dik J. Mevius,2 and Jaap T. van Dissel1*

Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden,1 Central Institute for Animal Disease Control, CIDC-Lelystad, Lelystad, The Netherlands2

Received 3 November 2003/ Returned for modification 23 December 2003/ Accepted 9 February 2004

MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella.

* Corresponding author. Mailing address: Department of Infectious Diseases, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Phone: 31-71-5262613. Fax: 31-71-5266758. E-mail: j.t.van_dissel{at}lumc.nl.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2292-2294, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2292-2294.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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