This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ender, M.
Right arrow Articles by Berger-Bächi, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ender, M.
Right arrow Articles by Berger-Bächi, B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2004, p. 2295-2297, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2295-2297.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Fitness Cost of SCCmec and Methicillin Resistance Levels in Staphylococcus aureus

Miriam Ender, Nadine McCallum, Rajan Adhikari,{dagger} and Brigitte Berger-Bächi*

Department of Medical Microbiology, University of Zürich, Zürich, Switzerland

Received 20 October 2003/ Returned for modification 23 January 2004/ Accepted 21 February 2004

Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8028 Zürich, Switzerland. Phone: 41 1 634 26 50. Fax: 41 1 634 49 06. E-mail: bberger{at}immv.unizh.ch.

{dagger} Present address: Department of Microbiology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2295-2297, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2295-2297.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Perichon, B., Courvalin, P. (2009). VanA-Type Vancomycin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 4580-4587 [Abstract] [Full Text]  
  • van der Mee-Marquet, N., Francois, P., Domelier, A.-S., Arnault, L., Girard, N., Schrenzel, J., Quentin, R., and the Bloodstream Infection Study Group of the R, (2009). Variable-Number Tandem Repeat Analysis and Multilocus Sequence Typing Data Confirm the Epidemiological Changes Observed with Staphylococcus aureus Strains Isolated from Bloodstream Infections. J. Clin. Microbiol. 47: 2863-2871 [Abstract] [Full Text]  
  • Foucault, M.-L., Courvalin, P., Grillot-Courvalin, C. (2009). Fitness Cost of VanA-Type Vancomycin Resistance in Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53: 2354-2359 [Abstract] [Full Text]  
  • Karauzum, H., Ferry, T., de Bentzmann, S., Lina, G., Bes, M., Vandenesch, F., Schmaler, M., Berger-Bachi, B., Etienne, J., Landmann, R. (2008). Comparison of Adhesion and Virulence of Two Predominant Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Clones and Clonal Methicillin-Susceptible S. aureus Isolates. Infect. Immun. 76: 5133-5138 [Abstract] [Full Text]  
  • Noto, M. J., Fox, P. M., Archer, G. L. (2008). Spontaneous Deletion of the Methicillin Resistance Determinant, mecA, Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 52: 1221-1229 [Abstract] [Full Text]  
  • Balsalobre, L., de la Campa, A. G. (2008). Fitness of Streptococcus pneumoniae Fluoroquinolone-Resistant Strains with Topoisomerase IV Recombinant Genes. Antimicrob. Agents Chemother. 52: 822-830 [Abstract] [Full Text]  
  • Noto, M. J., Kreiswirth, B. N., Monk, A. B., Archer, G. L. (2008). Gene Acquisition at the Insertion Site for SCCmec, the Genomic Island Conferring Methicillin Resistance in Staphylococcus aureus. J. Bacteriol. 190: 1276-1283 [Abstract] [Full Text]  
  • Haenni, M., Moreillon, P. (2008). Fitness Cost and Impaired Survival in Penicillin-Resistant Streptococcus gordonii Isolates Selected in the Laboratory. Antimicrob. Agents Chemother. 52: 337-339 [Abstract] [Full Text]  
  • Lee, S. M., Ender, M., Adhikari, R., Smith, J. M. B., Berger-Bachi, B., Cook, G. M. (2007). Fitness Cost of Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus aureus by Way of Continuous Culture. Antimicrob. Agents Chemother. 51: 1497-1499 [Abstract] [Full Text]  
  • Kusuma, C., Jadanova, A., Chanturiya, T., Kokai-Kun, J. F. (2007). Lysostaphin-Resistant Variants of Staphylococcus aureus Demonstrate Reduced Fitness In Vitro and In Vivo. Antimicrob. Agents Chemother. 51: 475-482 [Abstract] [Full Text]  
  • Waldron, D. E., Lindsay, J. A. (2006). Sau1: a Novel Lineage-Specific Type I Restriction-Modification System That Blocks Horizontal Gene Transfer into Staphylococcus aureus and between S. aureus Isolates of Different Lineages.. J. Bacteriol. 188: 5578-5585 [Abstract] [Full Text]  
  • McCallum, N., Karauzum, H., Getzmann, R., Bischoff, M., Majcherczyk, P., Berger-Bachi, B., Landmann, R. (2006). In Vivo Survival of Teicoplanin-Resistant Staphylococcus aureus and Fitness Cost of Teicoplanin Resistance.. Antimicrob. Agents Chemother. 50: 2352-2360 [Abstract] [Full Text]  
  • Sola, C., Cortes, P., Saka, H. A., Cordoba MRSA Collaborative Study Group, , Vindel, A., Bocco, J. L. (2006). Evolution and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Epidemic and Sporadic Clones in Cordoba, Argentina. J. Clin. Microbiol. 44: 192-200 [Abstract] [Full Text]  
  • Qi, W., Ender, M., O'Brien, F., Imhof, A., Ruef, C., McCallum, N., Berger-Bachi, B. (2005). Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in Zurich, Switzerland (2003): Prevalence of Type IV SCCmec and a New SCCmec Element Associated with Isolates from Intravenous Drug Users. J. Clin. Microbiol. 43: 5164-5170 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»