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Antimicrobial Agents and Chemotherapy, June 2004, p. 2302-2304, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2302-2304.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Effects of Albendazole Sulfoxide and Praziquantel against Taenia solium and Taenia crassiceps Cysts

Francisca Palomares,1 Guadalupe Palencia,2 Rodolfo Pérez,2 Dinora González-Esquivel,1 Nelly Castro,1 and Helgi Jung Cook1,3*

Laboratorio de Neuropsicofarmacología,1 Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía 14269,2 Facultad de Química, UNAM, México, D.F., México3

Received 10 September 2003/ Returned for modification 10 October 2003/ Accepted 8 February 2004

We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.

* Corresponding author. Mailing address: Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, Col. La Fama, Tlalpan 14269, México City, México. Phone and fax: (52) 54-24 08 08. E-mail: helgi{at}servidor.unam.mx.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2302-2304, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2302-2304.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Palomares-Alonso, F., Piliado, J. C., Palencia, G., Ortiz-Plata, A., Jung-Cook, H. (2007). Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts. J Antimicrob Chemother 59: 212-218 [Abstract] [Full Text]  
  • HELDWEIN, K., BIEDERMANN, H.-G., HAMPERL, W.-D., BRETZEL, G., LOSCHER, T., LAREGINA, D., FROSCH, M., BUTTNER, D. W., TAPPE, D. (2006). SUBCUTANEOUS TAENIA CRASSICEPS INFECTION IN A PATIENT WITH NON-HODGKIN'S LYMPHOMA.. Am J Trop Med Hyg 75: 108-111 [Abstract] [Full Text]  
  • Palomares, F., Palencia, G., Ambrosio, J. R., Ortiz, A., Jung-Cook, H. (2006). Evaluation of the efficacy of albendazole sulphoxide and praziquantel in combination on Taenia crassiceps cysts: in vitro studies. J Antimicrob Chemother 57: 482-488 [Abstract] [Full Text]  


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