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Antimicrobial Agents and Chemotherapy, June 2004, p. 2305-2307, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2305-2307.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles

Jacob M. Hornby* and Kenneth W. Nickerson

School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666

Received 8 December 2003/ Returned for modification 21 January 2004/ Accepted 17 February 2004

The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.

* Corresponding author. Present address: Division of Natural Sciences, Lewis-Clark State College, Lewiston, ID 83501. Phone: (208) 792-2441. Fax: (208) 792-2064. E-mail: jmhornby{at}lcsc.edu.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2305-2307, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2305-2307.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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