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Antimicrobial Agents and Chemotherapy, June 2004, p. 2331-2333, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2331-2333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

ELVIRA HSV, a Yield Reduction Assay for Rapid Herpes Simplex Virus Susceptibility Testing

Ruzena Stránská,1* Rob Schuurman,1 David R. Scholl,2 Joseph A. Jollick,2 Carl J. Shaw,2 Caroline Loef,1 Merjo Polman,1 and Anton M. van Loon1

Department of Virology, Eijkman-Winkler Center, University Medical Center Utrecht, Utrecht, The Netherlands,1 Diagnostic Hybrids, Inc., Athens, Ohio2

Received 6 September 2003/ Returned for modification 6 November 2003/ Accepted 20 February 2004

A colorimetric yield reduction assay, ELVIRA (enzyme-linked virus inhibitor reporter assay) HSV, was developed to determine the antiviral drug susceptibilities of herpes simplex virus (HSV). It uses an HSV-inducible reporter cell line. This simple and rapid assay has an objective readout, low inoculum size, and good reproducibility. The results correlate well with those of the plaque reduction assay.

* Corresponding author. Mailing address: Department of Virology, G04.614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Phone: 31 30 250 6526. Fax: 31 30 250 5426. E-mail: r.stranska{at}azu.nl.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2331-2333, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2331-2333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.