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Antimicrobial Agents and Chemotherapy, June 2004, p. 2334-2336, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2334-2336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

IMP-1 and a Novel Metallo-ß-Lactamase, VIM-6, in Fluorescent Pseudomonads Isolated in Singapore

Tse Hsien Koh,* Grace Chee Yeng Wang, and Li-Hwei Sng

Department of Pathology, Singapore General Hospital, Singapore 168608, Singapore

Received 25 August 2003/ Returned for modification 27 October 2003/ Accepted 10 February 2004

Four carbapenem-resistant Pseudomonas spp. were isolated from patients in Singapore. One Pseudomonas putida isolate contained a blaIMP-1 identical to that first described in Japan. The sequence of a variant blaIMP-1 in Pseudomonas fluorescens contained four silent mutations compared with the original sequence. The remaining P. putida isolates contained blaVIM-6, a novel VIM gene variant.

* Corresponding author. Mailing address: Department of Pathology, Singapore General Hospital, 1 Hospital Dr., 168608 Singapore, Singapore. Phone: 65-6321-4505. Fax: 65-6222-6826. E-mail: gptthk{at}sgh.com.sg.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2334-2336, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2334-2336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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