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Antimicrobial Agents and Chemotherapy, June 2004, p. 2334-2336, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2334-2336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

IMP-1 and a Novel Metallo-ß-Lactamase, VIM-6, in Fluorescent Pseudomonads Isolated in Singapore

Tse Hsien Koh,* Grace Chee Yeng Wang, and Li-Hwei Sng

Department of Pathology, Singapore General Hospital, Singapore 168608, Singapore

Received 25 August 2003/ Returned for modification 27 October 2003/ Accepted 10 February 2004

Four carbapenem-resistant Pseudomonas spp. were isolated from patients in Singapore. One Pseudomonas putida isolate contained a blaIMP-1 identical to that first described in Japan. The sequence of a variant blaIMP-1 in Pseudomonas fluorescens contained four silent mutations compared with the original sequence. The remaining P. putida isolates contained blaVIM-6, a novel VIM gene variant.

* Corresponding author. Mailing address: Department of Pathology, Singapore General Hospital, 1 Hospital Dr., 168608 Singapore, Singapore. Phone: 65-6321-4505. Fax: 65-6222-6826. E-mail: gptthk{at}sgh.com.sg.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2334-2336, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2334-2336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Poirel, L., Cabanne, L., Collet, L., Nordmann, P. (2006). Class II Transposon-Borne Structure Harboring Metallo-{beta}-Lactamase Gene blaVIM-2 in Pseudomonas putida.. Antimicrob. Agents Chemother. 50: 2889-2891 [Abstract] [Full Text]  
  • Walsh, T. R., Toleman, M. A., Poirel, L., Nordmann, P. (2005). Metallo-{beta}-Lactamases: the Quiet before the Storm?. Clin. Microbiol. Rev. 18: 306-325 [Abstract] [Full Text]  
  • Castanheira, M., Toleman, M. A., Jones, R. N., Schmidt, F. J., Walsh, T. R. (2004). Molecular Characterization of a {beta}-Lactamase Gene, blaGIM-1, Encoding a New Subclass of Metallo-{beta}-Lactamase. Antimicrob. Agents Chemother. 48: 4654-4661 [Abstract] [Full Text]  
  • Koh, T. H., Wang, G. C. Y., Sng, L.-H. (2004). Clonal Spread of IMP-1-Producing Pseudomonas aeruginosa in Two Hospitals in Singapore. J. Clin. Microbiol. 42: 5378-5380 [Abstract] [Full Text]  


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