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Antimicrobial Agents and Chemotherapy, June 2004, p. 2337-2340, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2337-2340.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Effect of Recombinant Human Growth Hormone on the In Vitro Activities of Antiretroviral Drugs against Human Immunodeficiency Virus Type 1

Mark A Wainberg,1* Bluma G. Brenner,1 Eric Daar,2 Joseph M. Gertner,3 Clement Olivier,4 and Susan Kenley3

McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada,1 Department of Medicine, Cedars-Sinai Medical Center Research Institute, University of California at Los Angeles School of Medicine, Los Angeles, California,2 Serono Inc., Rockland, Maryland,3 Serono International SA, Geneva, Switzerland4

Received 23 July 2003/ Returned for modification 9 October 2003/ Accepted 3 February 2004

We studied the effects of recombinant human growth hormone (r-hGH) on human immunodeficiency virus type 1 replication by growing both wild-type and drug-resistant variants of virus in the presence of various concentrations of eight different antiretroviral drugs. r-hGH had no significant effect on either viral replication or the 50% inhibitory concentrations of these compounds.

* Corresponding author. Mailing address: McGill AIDS Center, Jewish General Hospital, Lady Davis Institute, 3755 Cote St. Catherine Rd., Montreal, Quebec H3T 1E2, Canada. Phone: (514) 340-8260. Fax: (514) 340-7502. E-mail: mark.wainberg{at}mcgill.ca.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2337-2340, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2337-2340.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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