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Antimicrobial Agents and Chemotherapy, July 2004, p. 2704-2707, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2704-2707.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lysostaphin-Coated Catheters Eradicate Staphylococccus aureus Challenge and Block Surface Colonization

Anjali Shah, James Mond, and Scott Walsh*

Biosynexus, Inc., Gaithersburg, Maryland 20877

Received 31 July 2003/ Returned for modification 24 December 2003/ Accepted 8 March 2004

Lysostaphin is an endopeptidase that kills Staphylococcus aureus, a predominant organism in catheter-related infections. Lysostaphin-coated catheters prevented catheter colonization by several strains of S. aureus, and activity was maintained for at least 4 days. Prophylactic use of lysostaphin in catheters may help prevent the occurrence of catheter-related staphylococcal infections.

* Corresponding author. Mailing address: Biosynexus, Inc., 9119 Gaither Rd., Gaithersburg, MD 20877. Phone: (301) 987-1171. Fax: (301) 990-4990. E-mail: scottwalsh{at}biosynexus.com.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2704-2707, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2704-2707.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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