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Antimicrobial Agents and Chemotherapy, July 2004, p. 2730-2732, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2730-2732.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Micafungin Enhances Neutrophil Fungicidal Functions against Candida Pseudohyphae

Cristina Gil-Lamaignere, Stefanie Salvenmoser, Regina Hess, and Frank-Michael C. Müller*

Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, D-69120 Heidelberg, Germany

Received 3 December 2003/ Returned for modification 19 January 2004/ Accepted 19 March 2004

We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis. Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic (C. albicans) or additive (C. dubliniensis); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.

* Corresponding author. Mailing address: Pediatric Pulmonology and Infectious Diseases, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany. Phone: 49-6221-56-8435. Fax: 49-6221-56-4580. E-mail for Cristina Gil-Lamaignere: cris.gil{at}med.uni-heidelberg.de. E-mail for Frank-Michael C. Müller: Frank-Michael_Mueller{at}med.uni-heidelberg.de.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2730-2732, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2730-2732.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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