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Antimicrobial Agents and Chemotherapy, July 2004, p. 2733-2735, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2733-2735.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Proteomic Analysis of Azole Resistance in Candida albicans Clinical Isolates

Massoumeh Z. Hooshdaran,1,2 Katherine S. Barker,1,2 George M. Hilliard,3 Harald Kusch,4 Joachim Morschhäuser,4 and P. David Rogers1,2,5,6*

Departments of Pharmacy,1 Pharmaceutical Sciences, College of Pharmacy,5 Departments of Pediatrics,6 Molecular Sciences, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163,3 Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee 38103,2 Institüt für Molekulare Infektionsbiologie, Universität Würzburg, D-97070 Würzburg, Germany4

Received 16 December 2003/ Returned for modification 30 January 2004/ Accepted 12 March 2004

Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthesis pathway.

* Corresponding author. Mailing address: Children's Foundation Research Center of Memphis, Le Bonheur Children's Medical Center, 50 N. Dunlap St., Room 304, West Patient Tower, Memphis, TN 38103. Phone: (901) 572-5387. Fax: (901) 448-1741. E-mail: drogers{at}utmem.edu.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2733-2735, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2733-2735.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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