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Antimicrobial Agents and Chemotherapy, July 2004, p. 2739-2741, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2739-2741.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

No Findings of Dental Defects in Children Treated with Minocycline

Antonio Cascio,1* Chiara Di Liberto,2 Matteo D'Angelo,2 Chiara Iaria,3 Francesco Scarlata,1 Lucina Titone,1 and Giuseppina Campisi2

Istituto di Patologia Infettiva e Virologia, G. Di Cristina Hospital,1 Section of Oral Medicine, Department of Oral Sciences G. Messina, Università di Palermo, Palermo,2 Associazione Italiana per la Lotta contro le Malattie Infettive, Scuola di Specializzazione in Malattie Infettive, Università di Messina, Messina, Italy3

Received 8 October 2003/ Returned for modification 11 November 2003/ Accepted 24 February 2004

Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P > 0.2).


* Corresponding author. Present address: Associazione Italiana per la Lotta contro le Malattie Infettive, c/o Scuola di Specializzazione in Malattie Infettive, Università di Messina, Via Consolare Valeria n. 1, 98125 Messina, Italy. Phone: 39 090 221 2033. Fax: 39 090 2939512. E-mail: acascio{at}unime.it.


Antimicrobial Agents and Chemotherapy, July 2004, p. 2739-2741, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2739-2741.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.