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Antimicrobial Agents and Chemotherapy, July 2004, p. 2751-2752, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2751-2752.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Artesunate and Chloroquine Activities against Plasmodium vivax Gametocytes

Mathieu Nacher,1,2,3* Udomsak Silachamroon,1 Pratap Singhasivanon,1 Polrat Wilairatana,1 Weerapong Phumratanaprapin,1 Arnaud Fontanet,2 and Sornchai Looareesuwan1

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok,1 Shoklo Malaria Research Unit, Mae Sod, Thailand,2 Institut Pasteur, Unite de Recherche et d'Expertise, Epidemiologie des Maladies Emergentes, Paris, France3

Received 25 January 2004/ Returned for modification 14 March 2004/ Accepted 17 March 2004

The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated patients (n = 792) than in chloroquine-treated patients (n = 695) (RR = 0.29; 95% CI = 0.2 to 0.40; P < 0.0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria.

* Corresponding author. Mailing address: Centre Hospitalier de Cayenne, Avenue des Flamboyants, 97300 Cayenne, French Guiana. Phone: 594 395024. Fax: 594 395016. E-mail: m_nacher{at}lycos.com.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2751-2752, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2751-2752.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Baird, J. K. (2009). Resistance to Therapies for Infection by Plasmodium vivax. Clin. Microbiol. Rev. 22: 508-534 [Abstract] [Full Text]  


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