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Antimicrobial Agents and Chemotherapy, July 2004, p. 2753-2756, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2753-2756.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Dihydroethanoanthracene Derivatives as In Vitro Malarial Chloroquine Resistance Reversal Agents

Julie Millet,1,2 Marylin Torrentino-Madamet,1,2 Sandrine Alibert,2,3 Christophe Rogier,1,2 Christiane Santelli-Rouvier,2,3 Joel Mosnier,1,2 Eric Baret,1,2 Jacques Barbe,2,3 Daniel Parzy,1,2 and Bruno Pradines1,2*

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées,1 GERCTOP-UMR CNRS 6009, Faculté de Pharmacie,3 Institut Fédératif de la Recherche 48, Marseille, France2

Received 15 December 2003/ Returned for modification 28 January 2004/ Accepted 10 March 2004

The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24 chloroquine-resistant and 10 chloroquine-susceptible strains of Plasmodium falciparum from different countries. The 9,10-dihydroethanoanthracene derivatives clearly increase chloroquine susceptibility only in chloroquine-resistant isolates.

* Corresponding author. Mailing address: IMTSSA, Unité de Parasitologie, Bd Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France. Phone: 33 4 91 15 01 10. Fax: 33 4 91 15 01 64. E-mail: bruno.pradines{at}free.fr.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2753-2756, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2753-2756.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Millet, J., Alibert, S., Torrentino-Madamet, M., Rogier, C., Santelli-Rouvier, C., Bigot, P., Mosnier, J., Baret, E., Barbe, J., Parzy, D., Pradines, B. (2004). Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative. Antimicrob. Agents Chemother. 48: 4869-4872 [Abstract] [Full Text]  


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