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Antimicrobial Agents and Chemotherapy, July 2004, p. 2757-2759, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2757-2759.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

rpoB Mutations in Streptococcus mitis Clinical Isolates Resistant to Rifampin

Wafa Achour,1 Olfa Guenni,1 Marguerite Fines,2 Roland Leclercq,2* and Assia Ben Hassen1

Laboratoire du Centre National de Greffe de Moelle Osseuse, 1006 Tunis, Tunisia,1 Service de Microbiologie, CHU Côte de Nacre, 14003 Caen, France2

Received 4 September 2003/ Returned for modification 22 November 2003/ Accepted 3 March 2004

Activity of rifampin against 129 Streptococcus mitis isolates obtained from patients with hematologic cancer was investigated. One hundred twenty-five strains were susceptible to rifampin, and 4 were resistant (MIC = 32 to 64 µg/ml). Resistance to rifampin was related to mutations in the rpoB gene: His526Asn in three strains and His526Asp in one strain.

* Corresponding author. Mailing address: CHU de Caen, Service de Microbiologie, Ave. Côte de Nacre, 14033 Caen Cedex, France. Phone: (33) 02 31 06 45 72. Fax: (33) 02 31 06 45 73. E-mail: leclercq-r{at}chu-caen.fr

Antimicrobial Agents and Chemotherapy, July 2004, p. 2757-2759, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2757-2759.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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