AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edelstein, M.
Right arrow Articles by Stratchounski, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edelstein, M.
Right arrow Articles by Stratchounski, L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2004, p. 2808-2815, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.2808-2815.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Multiple Outbreaks of Nosocomial Salmonellosis in Russia and Belarus Caused by a Single Clone of Salmonella enterica Serovar Typhimurium Producing an Extended-Spectrum ß-Lactamase

M. Edelstein,1* M. Pimkin,1 T. Dmitrachenko,2 V. Semenov,2 N. Kozlova,3 D. Gladin,3 A. Baraniak,4 and L. Stratchounski1

Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, 214019,1 St. Petersburg State Medical Academy, St. Petersburg, 195067, Russia,3 Vitebsk State Medical University, Vitebsk, 210602, Belarus,2 National Institute of Public Health, Warsaw, 00-725, Poland4

Received 17 October 2003/ Returned for modification 4 January 2004/ Accepted 30 March 2004

Thirty-four cefotaxime-resistant Salmonella enterica serovar Typhimurium isolates representative of the isolates that caused outbreaks of gastroenteritis in 10 hospitals in seven regions of Russia and Belarus from 1994 to 2003 were analyzed. All isolates produced the CTX-M-5-like extended-spectrum ß-lactamase, which confers high-level resistance to cefotaxime and ceftriaxone and decreased susceptibility to ceftazidime. The blaCTX-M genes were located on small (7.4- to 12-kb) non-self-transferable plasmids approximately 20 bp downstream of the ISEcp1 insertion sequences. Some isolates carried additional conjugative plasmids mediating resistance to penicillin-inhibitor combinations and various non-ß-lactam agents, including tetracycline, chloramphenicol, gentamicin, tobramycin, and co-trimoxazole. Despite the minor differences in susceptibility patterns, all isolates were considered clonally related on the basis of arbitrarily primed PCR and pulsed-field gel electrophoresis analysis. The similarities of the restriction profiles of the CTX-M-coding plasmids further supported the clonal origin of these isolates.

* Corresponding author. Mailing address: Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, P.O. Box 5, 28, Krupskaya Str., Smolensk, 214019, Russia. Phone: 7-0812-611301. Fax: 7-0812-611294. E-mail: me{at}antibiotic.ru.

Antimicrobial Agents and Chemotherapy, August 2004, p. 2808-2815, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.2808-2815.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2004 by the American Society for Microbiology. All rights reserved.