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Antimicrobial Agents and Chemotherapy, August 2004, p. 3103-3106, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3103-3106.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Emergence in Italy of a Neisseria meningitidis Clone with Decreased Susceptibility to Penicillin

Paola Stefanelli, Cecilia Fazio, Arianna Neri, Tonino Sofia, and Paola Mastrantonio*

Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy

Received 8 March 2004/ Returned for modification 6 April 2004/ Accepted 13 April 2004

A rise in invasive diseases due to Neisseria meningitidis C:2b:P1.5 with decreased penicillin susceptibility occurred in Italy during the last 2 years. Real-time PCR identified the Peni phenotype, and the penA sequence revealed the mosaicism of the gene. Molecular analyses assigned the isolates to a single emergent clone of the hypervirulent A4 cluster.

* Corresponding author. Mailing address: Department of Infectious, Parasitic & Immuno-mediated Diseases, Istituto Superiore di Sanita', Viale Regina Elena 299, 00161-Rome, Italy. Phone: 390649902335. Fax: 390649387112. E-mail: pmastran{at}iss.it.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3103-3106, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3103-3106.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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