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Antimicrobial Agents and Chemotherapy, August 2004, p. 3122-3126, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3122-3126.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Distribution of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Mutation Patterns in 4,183 Persons Undergoing Genotypic Resistance Testing

Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California

Received 30 December 2003/ Returned for modification 20 February 2004/ Accepted 29 March 2004

In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

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