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Antimicrobial Agents and Chemotherapy, August 2004, p. 3127-3129, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3127-3129.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activity and Potency of an Intravenously Injected Antimicrobial Peptide and Its DL Amino Acid Analog in Mice Infected with Bacteria

Amir Braunstein,{dagger} Niv Papo,{dagger} and Yechiel Shai*

Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel

Received 28 January 2004/ Returned for modification 29 February 2004/ Accepted 19 April 2004

We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L9 (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.

* Corresponding author. Mailing address: Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel. Phone: 972-8-9342711. Fax: 972-8-9344112. E-mail: Yechiel.Shai{at}weizmann.ac.il.

{dagger} A.B. and N.P. contributed equally to the paper.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3127-3129, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3127-3129.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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