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Antimicrobial Agents and Chemotherapy, August 2004, p. 3133-3135, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3133-3135.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Activity of Orally Administered Clofazimine against Intracellular Mycobacterium tuberculosis in Whole-Blood Culture

Ernestas Janulionis, Carolina Sofer, Ho-Yeon Song, and Robert S. Wallis*

University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey

Received 25 February 2004/ Returned for modification 22 March 2004/ Accepted 26 April 2004

The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.

* Corresponding author. Mailing address: Department of Medicine, UMDNJ-NJMS, MSB I-503, 185 S. Orange Ave., Newark, NJ 07103. Phone: (973) 972-8778. Fax: (973) 972-8878. E-mail: r.wallis{at}umdnj.edu.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3133-3135, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3133-3135.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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