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Antimicrobial Agents and Chemotherapy, August 2004, p. 3136-3140, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3136-3140.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activities of Doripenem (S-4661) against Drug-Resistant Clinical Pathogens

Ronald N. Jones,1,2* Holly K. Huynh,1 and Douglas J. Biedenbach1

The JONES Group/JMI Laboratories, North Liberty, Iowa,1 Tufts University School of Medicine, Boston, Massachusetts2

Received 18 December 2003/ Returned for modification 14 March 2004/ Accepted 23 April 2004

Doripenem (formerly S-4661), a new 1-ß-methyl carbapenem, was challenged with a worldwide collection of 394 drug-refractory isolates. For endemic extended-spectrum ß-lactamase- and stably derepressed AmpC-producing enteric bacilli, the doripenem MICs at which 90% of the isolates were inhibited (MIC90s) were 0.03 to 0.5 µg/ml, generally lower than those of comparator carbapenems. A greater proportion of strains among carbapenem-resistant nonfermentative gram-negative bacilli were inhibited by doripenem at ≤4 µg/ml, and doripenem was the most active carbapenem (MIC90, 1 to 4 µg/ml) against penicillin-resistant streptococci.

* Corresponding author. Mailing address: The JONES Group/JMI Laboratories, Inc., 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: ronald-jones{at}jmilabs.com.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3136-3140, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3136-3140.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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