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Antimicrobial Agents and Chemotherapy, August 2004, p. 3141-3146, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3141-3146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Evidence that DNA in Antibiotic Preparations Is a Source of Antibiotic Resistance Genes in Bacteria from Animal or Human Sources

Susanna K. P. Lau, Patrick C. Y. Woo, Amanda P. C. To, Alexson T. K. Lau, and Kwok-yung Yuen*

Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong

Received 31 July 2003/ Returned for modification 2 January 2004/ Accepted 5 April 2004

Although DNA encoding antibiotic resistance has been discovered in antibiotic preparations, its significance for the development of antibiotic resistance in bacteria is unknown. No phylogenetic evidence was obtained for recent horizontal transfer of antibiotic resistance genes from antibiotic-producing organisms to bacteria from human or animal sources.

* Corresponding author. Mailing address: Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong. Phone: (852) 28554892. Fax: (852) 28551241. E-mail: hkumicro{at}hkucc.hku.hk.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3141-3146, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3141-3146.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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