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Antimicrobial Agents and Chemotherapy, August 2004, p. 3154-3158, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3154-3158.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effect of Granulocyte Colony-Stimulating Factor Combination Therapy on Efficacy of Posaconazole (SCH56592) in an Inhalation Model of Murine Pulmonary Aspergillosis

Andriani C. Patera,* Frederick Menzel, Craig Jackson, Joan K. Brieland,{dagger} Judy Halpern, Roberta Hare, Anthony Cacciapuoti, and David Loebenberg

Schering Plough-Research Institute, Kenilworth, New Jersey 07033

Received 29 July 2003/ Returned for modification 25 November 2003/ Accepted 25 April 2004

Using an inhalation model of pulmonary aspergillosis, we observed modest differences in the survival rates of mice treated with granulocyte colony-stimulating factor (G-CSF) and posaconazole (POS) and those treated with POS alone. This finding is in contrast to a previous report that suggested that G-CSF had a significant antagonistic effect on the antifungal activity of POS.

* Corresponding author. Mailing address: Schering-Plough Research Institute, K15-4-4800, 2015 Galloping Hill Rd., Kenilworth, NJ 07033. Phone: (908) 740-2651. Fax: (908) 740-3918. E-mail: andriani.patera{at}spcorp.com.

{dagger} Present address: Pfizer Global R&D, Ann Arbor, Mich.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3154-3158, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3154-3158.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ullmann, A. J., Krammes, E., Sommer, S., Buschmann, I., Jahn-Muehl, B., Cacciapuoti, A., Schmitt, H.-J. (2007). Efficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats. J Antimicrob Chemother 60: 1080-1084 [Abstract] [Full Text]  


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