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Antimicrobial Agents and Chemotherapy, August 2004, p. 3172-3174, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3172-3174.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CMY-13, a Novel Inducible Cephalosporinase Encoded by an Escherichia coli Plasmid

Laboratory of Bacteriology, Hellenic Pasteur Institute,¹ Department of Microbiology, Medical School, University of Athens,² Microbiology Division, National School of Public Health, Athens, Greece,⁴ Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy³

Received 18 December 2003/ Returned for modification 14 March 2004/ Accepted 13 April 2004

An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments.

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