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Antimicrobial Agents and Chemotherapy, August 2004, p. 3175-3178, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3175-3178.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis

Maria Rosalia Pasca, Paola Guglierame, Fabio Arcesi, Marco Bellinzoni, Edda De Rossi, and Giovanna Riccardi*

Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy

Received 22 December 2003/ Returned for modification 14 March 2004/ Accepted 23 April 2004

The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.

* Corresponding author. Mailing address: Department of Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy. Phone: 39 0382 505574. Fax: 39 0382 528496. E-mail: riccardi{at}ipvgen.unipv.it.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3175-3178, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3175-3178.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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