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Antimicrobial Agents and Chemotherapy, August 2004, p. 3185-3187, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3185-3187.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Remarkable Increase in Central Japan in 2001-2002 of Neisseria gonorrhoeae Isolates with Decreased Susceptibility to Penicillin, Tetracycline, Oral Cephalosporins, and Fluoroquinolones

Masayasu Ito,1 Mitsuru Yasuda,1 Shigeaki Yokoi,1 Shin-ichi Ito,1 Yoshito Takahashi,1 Satoshi Ishihara,1 Shin-ichi Maeda,2 and Takashi Deguchi1*

Department of Urology, Gifu University School of Medicine, Gifu 500-8705,1 Department of Urology, Toyota Memorial Hospital, Toyota 471-8513, Japan2

Received 18 November 2003/ Returned for modification 8 January 2004/ Accepted 21 April 2004

Four hundred sixty-two clinical isolates of Neisseria gonorrhoeae recovered from 1999 through 2002 in central Japan were examined for MICs of antimicrobial agents. The majority was sensitive to ceftriaxone and spectinomycin, but a remarkable increase in isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones was observed from 2001 through 2002.

* Corresponding author. Mailing address: Department of Urology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. Phone: 81-58-230-6337. Fax: 81-58-230-6339. E-mail: deguchit{at}cc.gifu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3185-3187, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3185-3187.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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