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Antimicrobial Agents and Chemotherapy, August 2004, p. 3193-3195, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3193-3195.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin

Michael Kresken,1* Beate Henrichfreise,1,2 Simone Bagel,1 Johannes Brauers,1 and Bernd Wiedemann1,2

Antiinfectives Intelligence GmbH, 53121 Bonn,1 Pharmazeutische Mikrobiologie, Rheinische-Friedrich-Wilhelms-Universität, 53115 Bonn, Germany2

Received 20 November 2003/ Returned for modification 1 March 2004/ Accepted 3 April 2004

Of 595 isolates of Streptococcus pneumoniae from outpatients with respiratory tract infections, collected from 17 microbiology laboratories, 14.1% were resistant to erythromycin. Eighty-three erythromycin-resistant isolates were genetically analyzed, 83.1% of which harbored the ermB gene. Only four isolates (4.8%) harbored the mefA gene. Telithromycin exhibited potent activity against all isolates.

* Corresponding author. Mailing address: Antiinfectives Intelligence GmbH, Immenburgstraße 20, 53121 Bonn, Germany. Phone: 49 228 44470611. Fax: 49 228 44470616. E-mail: michael.kresken{at}antiinfectives-intelligence.de.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3193-3195, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3193-3195.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wolter, N., Smith, A. M., Low, D. E., Klugman, K. P. (2007). High-Level Telithromycin Resistance in a Clinical Isolate of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51: 1092-1095 [Abstract] [Full Text]  


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