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Antimicrobial Agents and Chemotherapy, August 2004, p. 3200-3202, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3200-3202.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Susceptibility of Chlamydia trachomatis to Excipients Commonly Used in Topical Microbicide Formulations

M. F. Lampe,1,2* L. C. Rohan,3 M. C. Skinner,1,2 and W. E. Stamm2

Department of Laboratory Medicine,1 Division of Infectious Diseases, University of Washington, Seattle, Washington,2 Magee-Womens Research Institute, Pittsburgh, Pennsylvania3

Received 31 December 2003/ Returned for modification 5 February 2004/ Accepted 6 April 2004

Commonly used "inactive" pharmaceutical excipients were tested in a previously developed minimum cidal concentration assay to assess their ability to kill Chlamydia trachomatis topically. Sixteen excipients were evaluated in these studies under various conditions. A range of activities was found among the excipients that could be tested in our assay system.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195. Phone: (206) 598-2135. Fax: (206) 598-6189. E-mail: lampe{at}u.washington.edu.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3200-3202, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3200-3202.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sater, A. A. A., Ojcius, D. M., Meyer, M. P. (2008). Susceptibility of Chlamydia trachomatis to the Excipient Hydroxyethyl Cellulose: pH and Concentration Dependence of Antimicrobial Activity. Antimicrob. Agents Chemother. 52: 2660-2662 [Abstract] [Full Text]  


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