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Antimicrobial Agents and Chemotherapy, September 2004, p. 3419-3424, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3419-3424.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effect of Ertapenem Protein Binding on Killing of Bacteria

David E. Nix,* Kathryn R. Matthias, and Emily C. Ferguson

Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona

Received 3 February 2004/ Returned for modification 4 April 2004/ Accepted 11 May 2004

The effect of protein binding on the antimicrobial activity of ertapenem was evaluated using the bacterial kill rate and concentration-response studies. Various proportions of human serum were utilized to determine the total and free-drug concentrations using a validated high-performance liquid chromatography assay. The MICs and kill curves were determined for test isolates of Enterobacter cloacae and Staphylococcus aureus at various percentages of human serum. The killing of bacteria was analyzed in relation to the free and total concentrations of ertapenem at various proportions of human serum. It was determined that unbound ertapenem was responsible for the antimicrobial activity against the test isolates.

* Corresponding author. Mailing address: College of Pharmacy, University of Arizona, 1703 E. Mabel St., P.O. Box 210-207, Tucson, AZ 85721-0207. Phone: (520) 626-4814. Fax: (520) 626-7355. E-mail: nix{at}pharmacy.arizona.edu.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3419-3424, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3419-3424.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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